https://repositorio.ufba.br/handle/ri/7320
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Barbisan, Luís Fernando | - |
dc.contributor.author | Spinardi-Barbisan, Ana Lúcia Tozzi | - |
dc.contributor.author | Moreira, Eduardo Luís Trindade | - |
dc.contributor.author | Salvadori, Daisy Maria Favero | - |
dc.contributor.author | Ribeiro, Lúcia Regina | - |
dc.contributor.author | Eira, Augusto Ferreira da | - |
dc.contributor.author | Camargo, João Lauro Viana de | - |
dc.creator | Barbisan, Luís Fernando | - |
dc.creator | Spinardi-Barbisan, Ana Lúcia Tozzi | - |
dc.creator | Moreira, Eduardo Luís Trindade | - |
dc.creator | Salvadori, Daisy Maria Favero | - |
dc.creator | Ribeiro, Lúcia Regina | - |
dc.creator | Eira, Augusto Ferreira da | - |
dc.creator | Camargo, João Lauro Viana de | - |
dc.date.accessioned | 2012-12-07T14:29:38Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 1347-9032 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7320 | - |
dc.description | Texto Completo: acesso restrito. p. 188–192 | pt_BR |
dc.description.abstract | The modifying potential of crude extracts of the mushroom Agaricus blazei Murrill (Himematsutake) on the development and growth of glutathione S-transferase placental form (GST-P)-positive liver foci (liver preneoplastic lesion) was investigated in adult male Wistar rats. Six groups of animals were used. Groups 2 to 5 were given a single i.p. injection of 200 mg/kg b.w. of diethylnitrosamine (DEN) and groups 1 and 6 were treated with saline at the beginning of the experiment. After 2 weeks, animals of groups 3 to 6 were orally treated with three dose levels of aqueous extracts of the mushroom A. blazei (1.2, 5.6, 11.5, and 11.5 mg/ml of dry weight of solids) for 6 weeks. All animals were subjected to two-thirds partial hepatectomy at week 3 and sacrificed at week 8. Two hours before sacrifice, ten animals of each group were administered a single i.p injection of 100 mg/kg of bro-modeoxyuridine (BrdU). Apoptotic bodies and BrdU-positive hepatocyte nuclei were quantified in liver sections stained for hematoxylin and eosin (H&E) (eosinophilic foci) and simultaneously stained for GST-P expression (GST-P-positive foci), respectively. The 6-week treatment with A. blazei did not alter the development (number and size) of GST-P-positive foci and did not affect the growth kinetics of liver normal parenchyma or foci in DEN-initiated animals. Our results indicate that the treatment with aqueous extracts of the mushroom A. blazei during the post-initiation stage of rat liver carcinogenesis does not exert any protective effect against the development of GST-P-positive foci induced by DEN. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://onlinelibrary.wiley.com/doi/10.1111/j.1349-7006.2003.tb01417.x/pdf | pt_BR |
dc.title | Agaricus blazei (Himematsutake) does not alter the development of rat diethylnitrosamine-initiated hepatic preneoplastic foci | pt_BR |
dc.title.alternative | Cancer Science | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 94, n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
j.1349-7006.2003.tb01417.x.pdf Restricted Access | 525,02 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.