Campo DC | Valor | Idioma |
dc.contributor.author | Salvadori, Daisy M. F. | - |
dc.contributor.author | Ribeiro, Lúcia R. | - |
dc.contributor.author | Oliveira, Marília de Dirceu Machado de | - |
dc.contributor.author | Pereira, Carlos A. B. | - |
dc.contributor.author | Beçak, Willy | - |
dc.creator | Salvadori, Daisy M. F. | - |
dc.creator | Ribeiro, Lúcia R. | - |
dc.creator | Oliveira, Marília de Dirceu Machado de | - |
dc.creator | Pereira, Carlos A. B. | - |
dc.creator | Beçak, Willy | - |
dc.date.accessioned | 2012-12-11T18:02:20Z | - |
dc.date.available | 2012-12-11T18:02:20Z | - |
dc.date.issued | 1992 | - |
dc.identifier.issn | 0027-5107 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7400 | - |
dc.description | Texto completo: acesso restrito. p. 237-244 | pt_BR |
dc.description.abstract | The influence of ß-carotene on the clastogenicity of the indirect-acting mutagen cyclophosphamide (CPA) was investigated in mice, in vivo, for the induction of chromosome aberrations in bone marrow cells (BM). ß-Carotene (0.5, 1.0, 2.0, 5.0, 10, 25, 50, 100 and 200 mg/kg) was administered by gavage for 5 consecutive days. 4 h after the last treatment with ß-carotene, the mice were injected intraperitoneally with CPA, and the BM cells were fixed after 16, 24 and 32 h for the evaluation of the frequency of chromosome aberrations. The results showed that ß-carotene was effective in reducing chromosomal damage induced by CPA with the increase of its concentration up to a level after which this effect was not observed. This anticlastogenicity was better detected when the cells were fixed at 32 h, although a tendency in reducing the CPA clastogenicity was already observed at 16 and 24 h. Our results suggest that ß-carotene provides significant protection against the genotoxicity of CPA, although no dose-effect relationship on the frequencies of cells with chromosomal aberrations was observed. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | pt_BR |
dc.source | http://dx.doi.org/10.1016/0027-5107(92)90052-4 | pt_BR |
dc.subject | Antimutagenesis | pt_BR |
dc.subject | ß-Carotene | pt_BR |
dc.subject | Chromosome aberration | pt_BR |
dc.subject | Cyclophosphamide | pt_BR |
dc.title | The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide | pt_BR |
dc.title.alternative | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 265, n. 2 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (EMV)
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