https://repositorio.ufba.br/handle/ri/7515
Tipo: | Artigo de Periódico |
Título: | Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance |
Título(s) alternativo(s): | Toxicon |
Autor(es): | Barral-Netto, Manoel Von Sohsten, R. L. |
Autor(es): | Barral-Netto, Manoel Von Sohsten, R. L. |
Abstract: | M. Barral-Netto and R. L. von Sohsten. Serum kinetics of crotoxin from Crotalus durissus terrificus venom in mice: evidence for a rapid clearance. Toxicon29, 527–531, 1991.—We report on an ELISA for the detection of crotoxin with a detection limit of 1–3 pg/ml of sample. Cross-reactivity with other animal venoms occurred only at concentrations above 1 μg/ml. Serum kinetics of crotoxin were investigated in BALB/c mice after a single 10 μg s.c. dose of venom obtained from Crotalus durissus terrificus. Crotoxin levels were 254±141 ng/ml serum (View the MathML source) 15 min after venom injection, 3.9±0.5 ng/ml serum at 30 min and undetectable thereafter. The rapid clearance of crotoxin from the serum suggests that the test may be unsuitable for the clinical management of envenomation victims. |
Editora / Evento / Instituição: | Toxicon |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/7515 |
Data do documento: | 1991 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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5555555.pdf | 626,99 kB | Adobe PDF | Visualizar/Abrir |
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