https://repositorio.ufba.br/handle/ri/7525
Campo DC | Valor | Idioma |
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dc.contributor.author | Bautista, Ana Rita Pedreira Lapa | - |
dc.contributor.author | Moreira, E. L. T. | - |
dc.contributor.author | Batista, Márcio Santos | - |
dc.contributor.author | Miranda, Maria da Pureza Spínola | - |
dc.contributor.author | Gomes, I. C. S. | - |
dc.creator | Bautista, Ana Rita Pedreira Lapa | - |
dc.creator | Moreira, E. L. T. | - |
dc.creator | Batista, Márcio Santos | - |
dc.creator | Miranda, Maria da Pureza Spínola | - |
dc.creator | Gomes, I. C. S. | - |
dc.date.accessioned | 2012-12-14T11:59:01Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0278-6915 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7525 | - |
dc.description | Texto completo:acesso restrito. p. 625-629 | pt_BR |
dc.description.abstract | Increased human use of annatto (Bixa orellana L), a red yellow food colorant, demands generation of toxicity data. The toxic effects of annatto powder (bixin 27%) have been assessed following administration of a subacute regimen (4 weeks, 20 doses) in Wistar male and female rats. A full study with three dose levels was considered unnecessary since no sign of toxicity had been noted in a preliminary experiment with 1000 mg/kg body weight/day as was recommended by the OECD guideline. In this study, annatto administered by gavage at a dose level of 2000 mg/kg/day decreased male body weight gain, but had no effect on either food intake or food conversion efficiency. Haematological and plasma biochemical examination as well necropsy performed at the end of administration (29th day) and observation (43rd day) periods revealed no alterations related with annatto administration. Kidney apoptosis occurred in 20% treated female rats in restricted areas without proliferation or tubular segments modification. The precise nature of apoptosis was not investigated in the present study. These findings suggest that annatto was no toxic to the rat. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Elservier | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.fct.2003.11.007 | pt_BR |
dc.subject | Bixa orellana | pt_BR |
dc.subject | Annatto | pt_BR |
dc.subject | Bixin | pt_BR |
dc.subject | Food color | pt_BR |
dc.subject | Subacute toxicity | pt_BR |
dc.title | Subacute toxicity assessment of annatto in rat | pt_BR |
dc.title.alternative | Food and Chemical Toxicology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 42, n. 4 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (EMV) |
Arquivo | Descrição | Tamanho | Formato | |
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1-s2.0-S0278691503003442-main.pdf Restricted Access | 168,24 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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