https://repositorio.ufba.br/handle/ri/7847
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Castro, L. | - |
dc.contributor.author | Silva, E. de Castro e | - |
dc.contributor.author | Lima, A. K. S. | - |
dc.contributor.author | Souza, F. S. | - |
dc.contributor.author | Maldonado, I. | - |
dc.contributor.author | Macêdo, D. F. | - |
dc.contributor.author | Ferreira, M. G. | - |
dc.contributor.author | Santamaria, Guillermo Fernandez | - |
dc.creator | Castro, L. | - |
dc.creator | Silva, E. de Castro e | - |
dc.creator | Lima, A. K. S. | - |
dc.creator | Souza, F. S. | - |
dc.creator | Maldonado, I. | - |
dc.creator | Macêdo, D. F. | - |
dc.creator | Ferreira, M. G. | - |
dc.creator | Santamaria, Guillermo Fernandez | - |
dc.date.accessioned | 2013-01-14T14:06:58Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0091-3057 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/7847 | - |
dc.description | Texto completo: acesso restrito. p.443–448 | pt_BR |
dc.description.abstract | The aim of the present study was to investigate the effect of acute third ventricle injections of two different 5-HT4 receptor antagonists, GR 113808 and SB 204070, on water intake in different situations. Injections of 80 nmol/rat of both GR 113808 and SB 204070 were unable to modify water intake in normohydrated rats. Pretreatment with GR 113808 (40 and 80 nmol/rat) and SB 204070 (80 and 160 nmol/rat) blunted water intake after third ventricle injections of angiotensin II (9.6 pmol/rat) compared to saline-pretreated controls. Pretreatment with 80 nmol/rat of both antagonists potentiated drinking induced by third ventricle injections of carbachol (11.0 nmol/rat) compared to saline-pretreated control. In all doses employed, none of the compounds was able to modify water intake in dehydrated rats. A separate control test using one-bottle taste aversion paradigm indicated that the reduction in water intake observed in some of the present experiments could not be attributed to a drug-induced malaise. It is suggested that central 5-HT4 receptors exert a dualistic role on the control of water intake potentiating angiotensin II-induced drinking and inhibiting thirst induced by central cholinergic activation. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1016/S0091-3057(00)00226-4 | pt_BR |
dc.subject | 5-HT4 receptors | pt_BR |
dc.subject | Drinking behavior | pt_BR |
dc.subject | Third ventricle injections | pt_BR |
dc.title | Central 5-HT4 receptors and drinking behavior | pt_BR |
dc.title.alternative | Pharmacology Biochemistry and Behavior | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v.66, n.2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Biologia) |
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