https://repositorio.ufba.br/handle/ri/8192
Tipo: | Artigo de Periódico |
Título: | Meta-analysis about efficacy of anti-resorptive drugs in post-menopausal osteoporosis |
Título(s) alternativo(s): | Journal of Clinical Pharmacy and Therapeutics |
Autor(es): | Macedo, Jeane Meire Sales de Macedo, Cristiano Ricardo Bastos de Elkis, Helio Oliveira, I. R. de |
Autor(es): | Macedo, Jeane Meire Sales de Macedo, Cristiano Ricardo Bastos de Elkis, Helio Oliveira, I. R. de |
Abstract: | Objective: The purpose of this study was to compare the effect of three groups of anti-resorptive drugs in post-menopausal osteoporosis. Data sources: We collected data covering the period between 1983 and 1995, by first using MEDLINE. References retrieved were scanned further to identify additional papers. Study selection: Only randomized studies evaluating bone mass by means of dual-photon or dual energy densitometry over a period of 1 year were accepted. Data extraction: Studies were arranged into three drug groups. We used densitometry results after 1 year in all treatment or control groups. Factors which might interfere with the results were recorded for subsequent separate analysis. Data synthesis: The MEDLINE search identified almost 25,000 studies. On reading the abstracts, 275 trials appeared to be controlled trials and original copies were retrieved for detailed analysis. A total of 31 articles which satisfied the inclusion criteria were identified. The first meta-analysis included studies which compared oestrogens and placebo, and the global effect-size was 0·54 (95% CI 0·34, 0·73). The second meta-analysis compared calcitonins with placebo and produced an effect-size of 0·41 (95% CI 0·21, 0·61) The third analysis compared bisphosphonates and placebo and showed an effect-size of 0·87 (95% CI 0·68, 1·07). Only oestrogen dose affected the results found. Conclusions: Bisphosphonates had the greatest effect on bone mass in post-menopausal osteoporosis. |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/8192 |
Data do documento: | 1998 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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