https://repositorio.ufba.br/handle/ri/8359
Campo DC | Valor | Idioma |
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dc.contributor.author | Barnhart, Kurt T. | - |
dc.contributor.author | Devoto, Luigi | - |
dc.contributor.author | Pommer, Ricardo | - |
dc.contributor.author | Sir Pettermann, Teresa | - |
dc.contributor.author | Robinovic, Jorge | - |
dc.contributor.author | Coutinho, Elsimar Metzker | - |
dc.creator | Barnhart, Kurt T. | - |
dc.creator | Devoto, Luigi | - |
dc.creator | Pommer, Ricardo | - |
dc.creator | Sir Pettermann, Teresa | - |
dc.creator | Robinovic, Jorge | - |
dc.creator | Coutinho, Elsimar Metzker | - |
dc.date.accessioned | 2013-02-04T16:02:43Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0015-0282 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/8359 | - |
dc.description | Texto completo: acesso restrito. p.250–255 | pt_BR |
dc.description.abstract | Objective: To evaluate a nomegestrol acetate subdermal contraceptive implant's (Uniplant; Thermex, Monaco) effect on the hypothalamus-pituitary-ovarian axis. Design: A prospective clinical trial. Setting: San Borja-Arriarán Clinical Hospital, University of Chile, School of Medicine. Patient(s): Normally cycling healthy women. Intervention(s): Insertion of Uniplant. Main Outcome Measure(s): Luteinizing hormone pulse and endocrine profiles were assessed before, 48 hours after insertion, and after prolonged use of the implant. Result(s): Anovulation was noted in 100% of users in the first month. Seventy percent of subjects demonstrated follicular development with the absence of ovulation and an endocrine profile similar to the follicular phase: (LH pulse/8 hours 6.85 ± 0.67, LH amplitude 3.54 ± 0.65 mlU/mL (conversion factor to SI unit, 1.00), and E2 193 ± 29.4 pg/mL (conversion factor to SI unit, 3.67), whereas 30% demonstrated no follicular activity with an endocrine profile similar to the luteal phase: (LH pulse/8 hours; 3.66 ± 0.66, LH amplitude 5.76 ± 1.73 mlU/mL, and E2 67.5 ± 4 pg/mL. Clinical characteristics, serum gonadotropin concentration, and LH pulse characteristics failed to predict which subjects would initiate or remain devoid of follicular activity. Conclusion(s): Uniplant results in anovulation via two mechanisms: hypothalamic suppression in subjects who lack follicular development, and likely suppression of the pituitary LH surge in subjects who initiate follicular activity. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1016/S0015-0282(97)81906-1 | pt_BR |
dc.subject | Nomegestrol acetate subdermal implants | pt_BR |
dc.subject | LH pulse hypothalamic pituitary fimction | pt_BR |
dc.title | Neuroendocrine mechanism of anovulation in users of contraceptive subdermal implant of nomegestrol acetate (Uniplant) | pt_BR |
dc.title.alternative | Fertility and Sterility | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 67, n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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Barnhart.pdf Restricted Access | 735,48 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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