https://repositorio.ufba.br/handle/ri/8539
Campo DC | Valor | Idioma |
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dc.contributor.author | Barral-Netto, Manoel | - |
dc.contributor.author | Sohsten, R. L. Von | - |
dc.contributor.author | Teixeira, M. | - |
dc.contributor.author | Santos, Washington Luis Conrado dos | - |
dc.contributor.author | Pompeu, M. L. | - |
dc.contributor.author | Moreira, R. A. | - |
dc.contributor.author | Oliveira, J. T. A. | - |
dc.contributor.author | Cavada, B. S. | - |
dc.contributor.author | Falcoff, E. | - |
dc.contributor.author | Barral, Aldina Maria Prado | - |
dc.creator | Barral-Netto, Manoel | - |
dc.creator | Sohsten, R. L. Von | - |
dc.creator | Teixeira, M. | - |
dc.creator | Santos, Washington Luis Conrado dos | - |
dc.creator | Pompeu, M. L. | - |
dc.creator | Moreira, R. A. | - |
dc.creator | Oliveira, J. T. A. | - |
dc.creator | Cavada, B. S. | - |
dc.creator | Falcoff, E. | - |
dc.creator | Barral, Aldina Maria Prado | - |
dc.date.accessioned | 2013-02-19T16:26:27Z | - |
dc.date.issued | 1996 | - |
dc.identifier.issn | 0001-706X | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/8539 | - |
dc.description | Texto completo: acesso restrito. p.237–250 | pt_BR |
dc.description.abstract | In vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-γ (IFN-γ) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-γ production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-γ administration (although IFN-γ preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-γ neutralization with anti-IFN-γ monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-γ. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/0001-706X(95)00120-4 | pt_BR |
dc.subject | Leishmania amazonensi | pt_BR |
dc.subject | Leishmaniasis | pt_BR |
dc.subject | Leishmania | pt_BR |
dc.subject | Tegumentary leishmaniasis | pt_BR |
dc.subject | Experimental leishmaniasis | pt_BR |
dc.subject | Canavalia brasiliensis | pt_BR |
dc.subject | Interferon-γ | pt_BR |
dc.title | In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis | pt_BR |
dc.title.alternative | Acta Tropica | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 60, n. 4 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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Barral.pdf Restricted Access | 1,63 MB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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