https://repositorio.ufba.br/handle/ri/8579
Tipo: | Artigo de Periódico |
Título: | Comparative study on intermittent versus continuous use of a contraceptive pill administered by vaginal route |
Título(s) alternativo(s): | Contraception |
Autor(es): | Coutinho, Elsimar Metzker O'Dwyer Junior, Edson Barbosa, Ione Cristina Ping, Gu Zhi Shaaban, Mamdouh M. Oyoon, Mohamed Aboul Aleem, Hany Abdel |
Autor(es): | Coutinho, Elsimar Metzker O'Dwyer Junior, Edson Barbosa, Ione Cristina Ping, Gu Zhi Shaaban, Mamdouh M. Oyoon, Mohamed Aboul Aleem, Hany Abdel |
Abstract: | A multicenter, international, randomized, comparative trial was conducted to assess the acceptability, efficacy and safety of two different schedules of a contraceptive pill, containing 250 μg levonorgestrel and 50 μg ethinyl estradiol, administered by the vaginal route. One schedule of daily administration for 21 days with a seven-day interruption to allow withdrawal bleeding was compared to daily administration without interruption for bleeding. A total of 900 women were recruited in three countries, Brazil, Egypt and China; 7,090 women-months of vaginal pill use were recorded (3,364 using the pills intermittently and 3,726 continuously). Four undesired pregnancies occurred, one in Egypt and three in China, all four in women using the pills intermittently. There was a statistically significant difference (p = 0.486) in pregnancy rate between the two groups. There were no other significant differences in discontinuation rates despite marked differences in bleeding patterns, amenorrhea predominating in the continuous use group. Hemoglobin levels increased significantly in the two groups but hematocrit was significantly higher in the continuous use group. |
Palavras-chave: | contraceptive vaginal pill continuous vs. intermittent use |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/8579 |
Data do documento: | 1995 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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