https://repositorio.ufba.br/handle/ri/8637
Tipo: | Artigo de Periódico |
Título: | Pharmacokinetics of ethynyloestradiol in women from different populations |
Título(s) alternativo(s): | Contraception |
Autor(es): | Fotherby, K. Akpoviroro, J. Abdel-Rahman, H. A. Toppozada, H. K. Souza, J. Caetano de Coutinho, Elsimar Metzker Koetsawang, S. Nukulkarn, P. Sheth, U. K. Napa, M. K. Gopalan, S. Plunkett, E. R. Brenner, P. F. Hickey, M. V. Grech, E. S. Lichtenberg, R. Gual, C. Molina, R. Gomez-Rogers, C. Kwon, E. Kim, S. W. Chan, T. Ratnam, S. S. Landgren, B. M. Shearman, R. P. Goldzieher, J. W. Dozier, T. S. |
Autor(es): | Fotherby, K. Akpoviroro, J. Abdel-Rahman, H. A. Toppozada, H. K. Souza, J. Caetano de Coutinho, Elsimar Metzker Koetsawang, S. Nukulkarn, P. Sheth, U. K. Napa, M. K. Gopalan, S. Plunkett, E. R. Brenner, P. F. Hickey, M. V. Grech, E. S. Lichtenberg, R. Gual, C. Molina, R. Gomez-Rogers, C. Kwon, E. Kim, S. W. Chan, T. Ratnam, S. S. Landgren, B. M. Shearman, R. P. Goldzieher, J. W. Dozier, T. S. |
Abstract: | The pharmacokinetics of a dose of 501I g eth:nyloestradiol administered orally was studied in fourteen centres. lbsorption lr'arsa pid and the highest serum concentrations of total ethynyloestradiol were found in .,ost subjects at 1 h and by $4 h concentrations were less than 250 p:/':.l. Calculation of the half-lives for absorption, distribution and elildnation showed wide variations between subjects, the half-life of elimination varying from 2.; h to more than n0 h. Bioavailability as mensured by the area under the serum ethynyloestradiol concentration-tiniec urve also showed more th.an a ten-fold variation. Intra-centre differences in the various parameters measured were as large as the inter-centre differerccs. |
Editora / Evento / Instituição: | Contraception |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/8637 |
Data do documento: | 1981 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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555555ssss.pdf | 509,06 kB | Adobe PDF | Visualizar/Abrir |
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