Skip navigation
Universidade Federal da Bahia |
Repositório Institucional da UFBA
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/13325
Tipo: Artigo de Periódico
Título: Lack of effect of nucleotide-supplemented infant formula on the management of acute diarrhea in infants
Título(s) alternativo(s): Nutrition Research
Autor(es): Neri, Daniela Almeida
Mattos, Ângela Peixoto de
Ribeiro, Tereza Cristina Medrado
Mendes, Patrícia Silva de Almeida
Valois, Sandra Santos
Ribeiro Jr., Hugo da Costa
Autor(es): Neri, Daniela Almeida
Mattos, Ângela Peixoto de
Ribeiro, Tereza Cristina Medrado
Mendes, Patrícia Silva de Almeida
Valois, Sandra Santos
Ribeiro Jr., Hugo da Costa
Abstract: Nucleotides have been identified as conditionally essential nutrients. As prevention studies, conducted with nucleotide-supplemented formula, have shown statistically significant decrease in the risk of diarrhea, we tested the hypothesis that the consumption of nucleotide-supplemented formula during an acute diarrhea episode is associated with therapeutic effects in the treatment of infants with acute diarrhea and dehydration. A randomized, double-blind, controlled clinical trial was conducted in which patients were randomly assigned to 1 of 2 treatment groups. The “test” group consumed a nucleotide-supplemented infant formula and the “control” group consumed a nonsupplemented formula. Infants were accommodated in a metabolic unit where body weight, and all intakes and outputs were recorded at 24-hour intervals during hospitalization. Laboratory parameters including blood gases and electrolytes were monitored during hospitalization. Eighty-one male infants ranging in age from older than 1 month and younger than 1 year, with acute non-cholera diarrhea and dehydration were studied. Primary outcomes were stool output and duration of diarrhea and did not differ significantly between the groups, with a stool output of 304.2 (SD 254.0) vs 350.3 (SD 269.1) g/kg and a duration of diarrhea of 83.3 (SD 44.5) vs 88.8 (SD 46.6) for the test and control groups, respectively. Anemia was highly prevalent and breast-feeding practice was not frequent in both groups. The average energy intake and weight gain were similar in the 2 groups. This study demonstrated that nucleotide supplementation of infant formula during episodes of acute diarrhea has no therapeutic advantage compared to conventional infant formula.
Palavras-chave: Acute diarrhea
Children
Nucleotides
Nutritional management
Infant formula
País: Brasil
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/13325
Data do documento: 2009
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

Arquivos associados a este item:
Arquivo Descrição TamanhoFormato 
1-s2.0-S0271531709000402-main.pdf122,72 kBAdobe PDFVisualizar/Abrir
Mostrar registro completo do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.