Campo DC | Valor | Idioma |
dc.contributor.author | Santos, Cleiton S. | - |
dc.contributor.author | Macedo, Júlio O. | - |
dc.contributor.author | Bandeira, Maurício de Sousa | - |
dc.contributor.author | Chagas Júnior, Adenizar Delgado das | - |
dc.contributor.author | McBride, Alan John Alexander | - |
dc.contributor.author | McBride, Flavia Weykamp da Cruz | - |
dc.contributor.author | Reis, Mitermayer Galvão dos | - |
dc.contributor.author | Athanazio, Daniel Abensur | - |
dc.creator | Santos, Cleiton S. | - |
dc.creator | Macedo, Júlio O. | - |
dc.creator | Bandeira, Maurício de Sousa | - |
dc.creator | Chagas Júnior, Adenizar Delgado das | - |
dc.creator | McBride, Alan John Alexander | - |
dc.creator | McBride, Flavia Weykamp da Cruz | - |
dc.creator | Reis, Mitermayer Galvão dos | - |
dc.creator | Athanazio, Daniel Abensur | - |
dc.date.accessioned | 2013-11-03T14:39:25Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0022-2615 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13533 | - |
dc.description | Texto completo: acesso restrito. p.1101-1106 | pt_BR |
dc.description.abstract | The mouse disease model has the advantage of a broad array of immunological and genetic tools available for basic research. Some studies on transgenic and/or mutant mouse strains as models for experimental leptospirosis have been reported; however, the wider use of such models is hampered by a poor understanding of the outcome of experimental leptospiral infection among the different mouse strains available. Here, the outcome of infection by a virulent strain of Leptospira interrogans serogroup Icterohaemorrhagiae strain Cop was studied in four commonly used wild-type mouse strains: A, CBA, BALB/c and C57BL/6. The end points evaluated in this study were survival, presence of kidney lesions, leptospiral load in kidney samples, microscopic agglutination test titre and anti-leptospiral IgG antibody levels. As expected, none of the mouse strains were susceptible to lethal leptospirosis. However, these strains developed specific pathologies associated with sublethal leptospirosis. The A and C57BL/6 strains exhibited a high leptospiral load in kidney samples and the CBA and C57BL/6 strains developed severe inflammatory lesions, whilst the BALB/c strain proved to be the most resistant to subclinical leptospirosis. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1099/jmm.0.021089-0 | pt_BR |
dc.title | Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes | pt_BR |
dc.title.alternative | Journal of Medical Microbiology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 59, n. 9 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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