https://repositorio.ufba.br/handle/ri/13533
Tipo: | Artigo de Periódico |
Título: | Different outcomes of experimental leptospiral infection in mouse strains with distinct genotypes |
Título(s) alternativo(s): | Journal of Medical Microbiology |
Autor(es): | Santos, Cleiton S. Macedo, Júlio O. Bandeira, Maurício de Sousa Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flavia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur |
Autor(es): | Santos, Cleiton S. Macedo, Júlio O. Bandeira, Maurício de Sousa Chagas Júnior, Adenizar Delgado das McBride, Alan John Alexander McBride, Flavia Weykamp da Cruz Reis, Mitermayer Galvão dos Athanazio, Daniel Abensur |
Abstract: | The mouse disease model has the advantage of a broad array of immunological and genetic tools available for basic research. Some studies on transgenic and/or mutant mouse strains as models for experimental leptospirosis have been reported; however, the wider use of such models is hampered by a poor understanding of the outcome of experimental leptospiral infection among the different mouse strains available. Here, the outcome of infection by a virulent strain of Leptospira interrogans serogroup Icterohaemorrhagiae strain Cop was studied in four commonly used wild-type mouse strains: A, CBA, BALB/c and C57BL/6. The end points evaluated in this study were survival, presence of kidney lesions, leptospiral load in kidney samples, microscopic agglutination test titre and anti-leptospiral IgG antibody levels. As expected, none of the mouse strains were susceptible to lethal leptospirosis. However, these strains developed specific pathologies associated with sublethal leptospirosis. The A and C57BL/6 strains exhibited a high leptospiral load in kidney samples and the CBA and C57BL/6 strains developed severe inflammatory lesions, whilst the BALB/c strain proved to be the most resistant to subclinical leptospirosis. |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13533 |
Data do documento: | 2010 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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Cleiton S. Santos.pdf | 482,15 kB | Adobe PDF | Visualizar/Abrir |
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