https://repositorio.ufba.br/handle/ri/13895
Tipo: | Artigo de Periódico |
Título: | Prolactin secretion in hypothyroid endotoxemic rats: involvement of l-arginine and Nitric Oxide synthase |
Título(s) alternativo(s): | Shock |
Autor(es): | Rodriguez, Tânia Tavares Biscarde, Eduardo Ferreira da Silva Muniz, Relva de Freitas Diniz Goncalves Amoedo, Maurício Kauark Ramalho, Maria José Pedreira |
Autor(es): | Rodriguez, Tânia Tavares Biscarde, Eduardo Ferreira da Silva Muniz, Relva de Freitas Diniz Goncalves Amoedo, Maurício Kauark Ramalho, Maria José Pedreira |
Abstract: | The identification of nitric oxide (NO) within the hypothalamus and pituitary gland has suggested its role as modulator of the activity on hypothalamic-pituitary axis. Hypothalamic NO synthase (NOS) is known to be regulated by thyroid hormones. We investigated the effects of previous injection of N[omega pi]-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, and L-arginine (L-Arg), the substrate for NO synthesis, on prolactin (PRL) secretion, through the lipopolysaccharide (LPS)-induced inflammatory response in thyroidectomized (TX) rats. TX or sham-operated (N) rats were intraperitoneally (i.p.) injected with L-NAME (10 mg kg-1) or L-Arg (200 mg kg-1) or the same volume of vehicle (saline solution) 30 min before endotoxemia-induction with LPS at 250 µg (100 g body weight)-1, i.p.. In N rats, NO increased PRL release in response to endotoxemia, whereas in hypothyroid rats, NO appeared to have the opposite effect. Our data support the hypothesis that NO exerts a modulatory influence on PRL secretion after LPS-induced inflammatory response. |
Palavras-chave: | Lipopolysaccharide L-NAME L-arginine Hyroidectomy Endotoxemia Prolactin |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13895 |
Data do documento: | 2005 |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS) |
Arquivo | Descrição | Tamanho | Formato | |
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Rodriguez, Tania.pdf | 191,18 kB | Adobe PDF | Visualizar/Abrir |
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