Campo DC | Valor | Idioma |
dc.contributor.author | Noronha, Almério Libório Lopes de | - |
dc.contributor.author | Báfica, Andre Luiz Barbosa | - |
dc.contributor.author | Nogueira, Lucas | - |
dc.contributor.author | Barral, Aldina Maria Prado | - |
dc.contributor.author | Barral-Netto, Manoel | - |
dc.creator | Noronha, Almério Libório Lopes de | - |
dc.creator | Báfica, Andre Luiz Barbosa | - |
dc.creator | Nogueira, Lucas | - |
dc.creator | Barral, Aldina Maria Prado | - |
dc.creator | Barral-Netto, Manoel | - |
dc.date.accessioned | 2014-01-06T13:12:10Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0344-0338 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14266 | - |
dc.description | Texto completo: acesso restrito. p. 155-161 | pt_BR |
dc.description.abstract | Tuberculosis/HIV-1 co-infection is responsible for thousands of deaths each year, and previous studies have reported that co-infected individuals display major morphological alterations in tissue granulomas. The purpose of this study was to evaluate immunohistopathological characteristics in lung tissues from pulmonary TB/HIV-1-co-infected individuals. Following autopsy, tuberculosis-positive HIV-1-negative cases displayed granulomas with normal architecture, mainly composed of a mononuclear infiltrate with typical epithelioid, as well as giant cells, and exhibiting caseous necrosis. In contrast, lesions from the TB/HIV-1-co-infected group showed extensive necrosis, poorly formed granulomas, and a marked presence of polymorphonuclear cells. More importantly, TNF staining was greatly reduced in the TB/HIV-1-co-infected individuals. Our data suggest that HIV-1 infection alters the organization of pulmonary granulomas by modulating TNF and, possibly, cell trafficking, leading to an impaired anti-tuberculosis response. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.prp.2007.10.008 | pt_BR |
dc.subject | Mycobacterium tuberculosis | pt_BR |
dc.subject | Autopsy | pt_BR |
dc.subject | Granuloma | pt_BR |
dc.subject | HIV | pt_BR |
dc.subject | TNF | pt_BR |
dc.title | Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production | pt_BR |
dc.title.alternative | Pathology - Research and Practice | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 204, n. 3 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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