https://repositorio.ufba.br/handle/ri/14266
Tipo: | Artigo de Periódico |
Título: | Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production |
Título(s) alternativo(s): | Pathology - Research and Practice |
Autor(es): | Noronha, Almério Libório Lopes de Báfica, Andre Luiz Barbosa Nogueira, Lucas Barral, Aldina Maria Prado Barral-Netto, Manoel |
Autor(es): | Noronha, Almério Libório Lopes de Báfica, Andre Luiz Barbosa Nogueira, Lucas Barral, Aldina Maria Prado Barral-Netto, Manoel |
Abstract: | Tuberculosis/HIV-1 co-infection is responsible for thousands of deaths each year, and previous studies have reported that co-infected individuals display major morphological alterations in tissue granulomas. The purpose of this study was to evaluate immunohistopathological characteristics in lung tissues from pulmonary TB/HIV-1-co-infected individuals. Following autopsy, tuberculosis-positive HIV-1-negative cases displayed granulomas with normal architecture, mainly composed of a mononuclear infiltrate with typical epithelioid, as well as giant cells, and exhibiting caseous necrosis. In contrast, lesions from the TB/HIV-1-co-infected group showed extensive necrosis, poorly formed granulomas, and a marked presence of polymorphonuclear cells. More importantly, TNF staining was greatly reduced in the TB/HIV-1-co-infected individuals. Our data suggest that HIV-1 infection alters the organization of pulmonary granulomas by modulating TNF and, possibly, cell trafficking, leading to an impaired anti-tuberculosis response. |
Palavras-chave: | Mycobacterium tuberculosis Autopsy Granuloma HIV TNF |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14266 |
Data do documento: | 2008 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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1-s2.0-S0344033807002464-main.pdf | 1,21 MB | Adobe PDF | Visualizar/Abrir |
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