Campo DC | Valor | Idioma |
dc.contributor.author | Santos, B. L. | - |
dc.contributor.author | Silva, A. R. | - |
dc.contributor.author | Pitanga, B. P. S. | - |
dc.contributor.author | Sousa, C. S. | - |
dc.contributor.author | Grangeiro, M. S. | - |
dc.contributor.author | Fragomeni, B. O. | - |
dc.contributor.author | Coelho, P. L. C. | - |
dc.contributor.author | Oliveira, M. N. | - |
dc.contributor.author | Menezes Filho, N. J. | - |
dc.contributor.author | Costa, Maria de Fátima Dias | - |
dc.contributor.author | El-Bachá, Ramon dos Santos | - |
dc.contributor.author | Velozo, Eudes da Silva | - |
dc.contributor.author | Sampaio, G. P. | - |
dc.contributor.author | Freire, S. M. | - |
dc.contributor.author | Tardy, Marcienne Bloch | - |
dc.contributor.author | Costa, Silvia Lima | - |
dc.creator | Santos, B. L. | - |
dc.creator | Silva, A. R. | - |
dc.creator | Pitanga, B. P. S. | - |
dc.creator | Sousa, C. S. | - |
dc.creator | Grangeiro, M. S. | - |
dc.creator | Fragomeni, B. O. | - |
dc.creator | Coelho, P. L. C. | - |
dc.creator | Oliveira, M. N. | - |
dc.creator | Menezes Filho, N. J. | - |
dc.creator | Costa, Maria de Fátima Dias | - |
dc.creator | El-Bachá, Ramon dos Santos | - |
dc.creator | Velozo, Eudes da Silva | - |
dc.creator | Sampaio, G. P. | - |
dc.creator | Freire, S. M. | - |
dc.creator | Tardy, Marcienne Bloch | - |
dc.creator | Costa, Silvia Lima | - |
dc.date.accessioned | 2014-03-13T18:23:05Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0308-8146 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14748 | - |
dc.description | Texto completo: acesso restrito. p. 404–411 | pt_BR |
dc.description.abstract | In this study, we investigated the effects of the flavonoid rutin (3,3′,4′,5,7-pentahydroxyflavone-3-rutinoside) on glioma cells, using the highly proliferative human cell line GL-15 as a model. We observed that rutin (50–100 μM) reduced proliferation and viability of GL-15 cells, leading to decreased levels of ERK1/2 phosphorylation (P-ERK1/2) and accumulation of cells in the G2 phase of the cell cycle. On the other hand, 87.4% of GL-15 cells exposed to 100 μM rutin entered apoptosis, as revealed by flow cytometry after AnnexinV/PI staining. Nuclear condensation and DNA fragmentation were also observed, further confirming that apoptosis had occurred. Moreover, the remaining cells that were treated with 50 μM rutin presented a morphological pattern of astroglial differentiation in culture, characterised by a condensed cell body and thin processes with overexpression of GFAP. Because of its capacity to induce differentiation and apoptosis in cultured human glioblastoma cells, rutin could be considered as a potential candidate for malignant gliomas treatment. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.foodchem.2010.12.131 | pt_BR |
dc.subject | Rutin | pt_BR |
dc.subject | Flavonoid | pt_BR |
dc.subject | Gliomas | pt_BR |
dc.subject | Apoptosis | pt_BR |
dc.subject | Differentiation | pt_BR |
dc.subject | P-ERK | pt_BR |
dc.subject | GFAP | pt_BR |
dc.title | Antiproliferative, proapoptotic and morphogenic effects of the flavonoid rutin on human glioblastoma cells | pt_BR |
dc.title.alternative | Food Chemistry | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 127, n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS)
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