Campo DC | Valor | Idioma |
dc.contributor.author | Monteiro, Adriano de Souza Santos | - |
dc.contributor.author | Oliveira, Eduardo Gomes de | - |
dc.contributor.author | Santos, Djanilson Barbosa dos | - |
dc.contributor.author | Cordeiro, Soraia Machado | - |
dc.contributor.author | Couto, Ricardo David | - |
dc.contributor.author | Couto, Fábio David | - |
dc.creator | Monteiro, Adriano de Souza Santos | - |
dc.creator | Oliveira, Eduardo Gomes de | - |
dc.creator | Santos, Djanilson Barbosa dos | - |
dc.creator | Cordeiro, Soraia Machado | - |
dc.creator | Couto, Ricardo David | - |
dc.creator | Couto, Fábio David | - |
dc.date.accessioned | 2021-09-11T10:30:06Z | - |
dc.date.available | 2021-09-11T10:30:06Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | MONTEIRO, A. S. S. et al. Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect?. Journal of Medical Microbiology, v. 70, n. 9, p. 001414, 2021. | pt_BR |
dc.identifier.issn | 0022-2615 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/34218 | - |
dc.description.abstract | Introduction: Sickle cell disease (SCD) children have a high susceptibility to pneumococcal infection. For this reason, they are routinely immunized with pneumococcal vaccines and use antibiotic prophylaxis (AP).
Hypothesis/Gap Statement: Yet, little is known about SCD children’s gut microbiota. If antibiotic-resistant Enterobacterales may colonize people on AP, we hypothesized that SCD children on AP are colonized by resistant enterobacteria species.
Objective: To evaluate the effect of continuous AP on Enterobacterales gut colonization from children with SCD.
Methodology: We analysed 30 faecal swabs from SCD children on AP and 21 swabs from children without the same condition. Enterobacterales was isolated on MacConkey agar plates and identified by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) (bioMérieux, Marcy l'Etoile, France). We performed the antibiogram by Vitek 2 system (bioMérieux, Marcy l'Etoile, France), and the resistance genes were identified by multiplex PCR.
Results: We found four different species with resistance to one or more different antibiotic types in the AP-SCD children’s group: Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, and Citrobacter farmeri. Colonization by resistant E. coli was associated with AP (prevalence ratio 2.69, 95% confidence interval [CI], 1.98–3.67, P<0.001). Strains producing extended-spectrum β-lactamases (ESBL) were identified only in SCD children, E. coli, 4/30 (13%), and K. pneumoniae, 2/30 (7%). The ESBL-producing Enterobacterales were associated with penicillin G benzathine use (95 % CI, 22.91–86.71, P<0.001). CTX-M-1 was the most prevalent among ESBL-producers (3/6, 50%), followed by CTX-M-9 (2/6, 33%), and CTX-M-2 (1/6, 17%).
Conclusion: Resistant enterobacteria colonize SCD children on AP, and this therapy raises the chance of ESBL-producing Enterobacterales colonization. Future studies should focus on prophylactic vaccines as exclusive therapy against pneumococcal infections. | pt_BR |
dc.description.sponsorship | This work was supported by the Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB) - Brasil [grant code SUS0036/2018]; and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Brasil [grant code 001]. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Journal of Medical Microbiology, Microbiology Society | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | https://doi.org/10.1099/jmm.0.001414 | pt_BR |
dc.subject | Sickle cell disease | pt_BR |
dc.subject | Antibiotic prophylaxis | pt_BR |
dc.subject | Gut microbiota | pt_BR |
dc.subject | Enterobacterales | pt_BR |
dc.subject | Multidrug resistance | pt_BR |
dc.subject | Extended-spectrum β-lactamase (ESBL)-producing Enterobacterales | pt_BR |
dc.title | Sickle cell disease children’s gut colonization by extended-spectrum β-lactamase (ESBL)-producing Enterobacterales: an antibiotic prophylaxis effect? | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | United Kingdom | pt_BR |
dc.identifier.number | v.70, n.9 | pt_BR |
dc.publisher.country | Brasil | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (PPGFAR)
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