Desenvolvimento de processo secagem em etapa única de nanopartículas poliméricas para a obtenção de insumos dermatológicos

Abstract

The Eudragit® family of copolymers is derived from acrylic acid, methacrylic acid, and their esters, which can be used in the development of polymeric nanoparticles to obtain controlled release systems in order to enable the administration of bioactive molecules that are unviable in conventional formulations. In the first part of this work, we reviewed the literature from the last seven years to observe the development of nanoparticles for topical use that used Eudragit® types S, L, RS and RL. The results demonstrated that the choice of polymer is made based on the physicochemical characteristics that increase the interaction of the pharmaceutical form with the skin and mucous membranes. Particles with positive charges and reduced size interact with physiological membranes that are negatively charged, improving drug efficacy. In contrast, particles with a negative surface and dependent pH can be directly released to specific locations, reducing adverse effects. In the experimental stage, a drying process for polymeric nanoparticles with the Eudragit® L100 polymer was developed in a single step to obtain dermatological supplies. The nanoparticles obtained were dried using the Spray Drying technique without the solvent evaporation step, thus reducing production time. The formulations obtained were characterized in their dry form and after incorporation into a dermatological base in order to observe their physicochemical characteristics. As a result, a water-soluble powder was obtained with characteristics similar to the original nanoparticles, thus enabling the development of different nanotechnological inputs to be used in the medicine and cosmetics industry.