Dinapenia, função tireoidiana e polimorfismo D2-ORFA-ASP3 (RS12885300): estudo transversal em mulheres idosas

Abstract

Introduction: Dynapenia is the loss of muscle strength and power related to senescence. To diagnose dynapenia, a manual dynamometer is used, which when pressed will emit a value that represents the palmar pressure force (FPP), The criterion for classifying dynapenia is HGS < 26 kg for men and < 16 kg for women The gland The thyroid is responsible for the production and secretion of triiodothyronine (T3) and thyroxine (T4) hormones, which play an important role in body metabolism. Muscle tissue is an important target of thyroid hormone action, so thyroid hormones exert influences on the biochemistry of muscle cells. With population aging, the functioning of the neuromuscular system is naturally at risk of having its capacity for strength and muscular endurance compromised. Loss of strength and muscle mass provide functional limitations for the elderly, which is a factor that generates many pathological processes associated with increased morbidity and mortality. Objective: To evaluate the relationship between skeletal muscle mass, dynapenia, thyroid function and the D2-ORFa-Gly3Asp polymorphism of the DIO2 gene in elderly women at the UATI (UNEB, Salvador, Bahia). Material and Methods: Cross-sectional study carried out with elderly women enrolled in the UATI, a socioeconomic and anthropometric questionnaire was applied. After blood collection, genotyping was performed to investigate possible influences of the polymorphism on the performance of thyroid function. Participants who were male or who had thyroid alterations or diseases, in addition to using medication that altered the thyroid axis, were excluded. Results: The sample had 66 participants, Of these, 8 were diagnosed with dynapenia, they had dynapenic obesity and malnutrition, according to the protocols used. No statistical significance was found between hormonal tests, dynapenia and the D2-ORFa-Gly3Asp polymorphism Conclusion The data presented here show that elderly people from an active population are less likely to have dynapenia, the score value present in the MNA indicates a higher correlation between risk of malnutrition and dynapenic status. There was no association between serum levels of T3, T4, TSH and the D2-ORFa-Gly3Asp polymorphism in the elderly Keywords: Dynapenia, obesity, malnutrition, Thyroid function, T3l, T4l, TSH, aging, muscle mass.