https://repositorio.ufba.br/handle/ri/6508
Tipo: | Artigo de Periódico |
Título: | HEV, TTV and GBV-C/HGV markers in patients with acute viral hepatitis |
Título(s) alternativo(s): | Brazilian Journal of Medical and Biological Research |
Autor(es): | Lyra, André Castro Pinho, João Renato Rebello Silva, L.K. Sousa, L. Saraceni, C. P. Braga, Eduardo Lorens Pereira, J. E. Zarife, Maria Alice Sant'anna Lyra, Luiz Guilherme Costa |
Autor(es): | Lyra, André Castro Pinho, João Renato Rebello Silva, L.K. Sousa, L. Saraceni, C. P. Braga, Eduardo Lorens Pereira, J. E. Zarife, Maria Alice Sant'anna Lyra, Luiz Guilherme Costa |
Abstract: | he aim of the present study was to evaluate the prevalence of HEV, TTV and GBV-C/GBV-C/HGV in patients with acute viral hepatitis A, B and non-A-C. We evaluated sera of 94 patients from a sentinel program who had acute hepatitis A (N = 40), B (N = 42) and non-A-C (N = 12); 71 blood donors served as controls. IgM and anti-HEV IgG antibodies were detected by enzyme immunoassay using commercial kits. TTV and GBV-C/HGV were detected by nested PCR; genotyping was done by sequencing and phylogenetic analysis. Anti-HEV IgG was present in 38, 10 and 17% of patients with hepatitis A, B and non-A-C. Four patients with hepatitis A and 1 with non-A-C hepatitis also had anti-HEV IgM detected in serum. TTV was detected in 21% of patients with acute hepatitis and in 31% of donors. GBV-C/HGV was detected in 9% of patients with hepatitis, and in 10% of donors. We found TTV isolates of genotypes 1, 2, 3, and 4 and GBV-C/HGV isolates of genotypes 1 and 2. Mean aminotransferase levels were lower in patients who were TTV or GBV-C/HGV positive. In conclusion, the detection of anti-HEV IgM in some acute hepatitis A cases suggests co-infection with HEV and hepatitis E could be the etiology of a few cases of sporadic non-A-C hepatitis in Salvador, Brazil. TTV genotype 1, 2, 3 and 4 isolates and GBV-C/HGV genotype 1 and 2 strains are frequent in the studied population. TTV and GBV-C/HGV infection does not appear to have a role in the etiology of acute hepatitis. |
Palavras-chave: | Acute hepatitis Hepatitis E TTV GBV-C/HGV Genotype Brazil |
Editora / Evento / Instituição: | Scielo |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6508 |
Data do documento: | 2005 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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