https://repositorio.ufba.br/handle/ri/6979
Tipo: | Artigo de Periódico |
Título: | High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1 |
Título(s) alternativo(s): | Brazilian Journal of Medical and Biological Research |
Autor(es): | Leite Primo, Janeusa Rita Siqueira, I. Nascimento, M. C. F. Oliveira, M. F. Farré, Lourdes Carvalho Filho, Edgar Marcelino de Bittencourt, Achilea Candida Lisboa |
Autor(es): | Leite Primo, Janeusa Rita Siqueira, I. Nascimento, M. C. F. Oliveira, M. F. Farré, Lourdes Carvalho Filho, Edgar Marcelino de Bittencourt, Achilea Candida Lisboa |
Abstract: | Salvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. HTLV-1 carriers may develop a variety of diseases such as adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). IDH is a chronic and severe form of childhood exudative and infective dermatitis involving mainly the scalp, neck and ears. It has recently been observed that 30% of patients with IDH develop juvenile HAM/TSP. The replication of HTLV-1 has been reported to be greater in adult HAM/TSP patients than in asymptomatic HTLV-1 carriers. In the current study, the proviral load of 28 children and adolescents with IDH not associated with HAM/TSP was determined and the results were compared to those obtained in 28 HTLV-1 adult carriers and 28 adult patients with HAM/TSP. The proviral load in IDH patients was similar to that of patients with HAM/TSP and much higher than that found in HTLV-1 carriers. The high levels of proviral load in IDH patients were not associated with age, duration of illness, duration of breast-feeding, or activity status of the skin disease. Since proviral load is associated with neurological disability, these data support the view that IDH patients are at high risk of developing HAM/TSP. |
Palavras-chave: | Infective dermatitis associated with HTLV-1 HTLV-1 associated myelopathy/tropical spastic paraparesis HTLV-1 proviral loads |
Editora / Evento / Instituição: | Brazilian Journal of Medical and Biological Research |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/6979 |
Data do documento: | Ago-2009 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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Primo, J..pdf | 200,87 kB | Adobe PDF | Visualizar/Abrir |
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