Skip navigation
Universidade Federal da Bahia |
Repositório Institucional da UFBA
Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/7847
Tipo: Artigo de Periódico
Título: Central 5-HT4 receptors and drinking behavior
Título(s) alternativo(s): Pharmacology Biochemistry and Behavior
Autor(es): Castro, L.
Silva, E. de Castro e
Lima, A. K. S.
Souza, F. S.
Maldonado, I.
Macêdo, D. F.
Ferreira, M. G.
Santamaria, Guillermo Fernandez
Autor(es): Castro, L.
Silva, E. de Castro e
Lima, A. K. S.
Souza, F. S.
Maldonado, I.
Macêdo, D. F.
Ferreira, M. G.
Santamaria, Guillermo Fernandez
Abstract: The aim of the present study was to investigate the effect of acute third ventricle injections of two different 5-HT4 receptor antagonists, GR 113808 and SB 204070, on water intake in different situations. Injections of 80 nmol/rat of both GR 113808 and SB 204070 were unable to modify water intake in normohydrated rats. Pretreatment with GR 113808 (40 and 80 nmol/rat) and SB 204070 (80 and 160 nmol/rat) blunted water intake after third ventricle injections of angiotensin II (9.6 pmol/rat) compared to saline-pretreated controls. Pretreatment with 80 nmol/rat of both antagonists potentiated drinking induced by third ventricle injections of carbachol (11.0 nmol/rat) compared to saline-pretreated control. In all doses employed, none of the compounds was able to modify water intake in dehydrated rats. A separate control test using one-bottle taste aversion paradigm indicated that the reduction in water intake observed in some of the present experiments could not be attributed to a drug-induced malaise. It is suggested that central 5-HT4 receptors exert a dualistic role on the control of water intake potentiating angiotensin II-induced drinking and inhibiting thirst induced by central cholinergic activation.
Palavras-chave: 5-HT4 receptors
Drinking behavior
Third ventricle injections
URI: http://www.repositorio.ufba.br/ri/handle/ri/7847
Data do documento: 2000
Aparece nas coleções:Artigo Publicado em Periódico (Biologia)

Arquivos associados a este item:
Não existem arquivos associados a este item.
Mostrar registro completo do item Visualizar estatísticas


Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.